Endocrine Abstracts

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Background: Continuous subcutaneous insulin infusion (CSII) is proving superior in reducing HbA1c compared to multiple daily injections (MDI) in both the adult and paediatric populations. This study aims to compare the two methods, and evaluate the importance of education when starting insulin pump therapy in children.Design: Patients who attended a ‘pump school’ provided by the Royal Manchester Children’s Hospital between January 2010 and...

Clinical, epidemiological and in-vitro studies have found evidence for an association between Vitamin D and diabetes. Vitamin D receptors are found on pancreatic beta-cells, suggesting they have a role in glycaemic control. Vitamin D analogues inhibit inflammatory cytokines involved in destruction of Beta-cells. This study aimed to assess the relationship between Vitamin D and glycaemic control, as measured by HbA1C, in a Type 1 (T1) diabetic paediatric population. HbA1C value...

Maintaining glycaemic control within recommended levels is crucial to minimise vascular complications associated with type 1 diabetes (T1D). Vitamin D is recognised as a vascular growth-factor. Detection of its receptors on pancreatic β-cells suggests it may have a role in glycaemic control. This study aimed to assess determinants of HbA1C including the potential influence of vitamin D status in a T1 diabetic paediatric population.Methods: Patients ...